Wesley College opened on 11 January 1866, at its St Kilda Road Campus and began with just one student, Freddie Binks. The College now has become one of Australia's leading coeducational, multi-campus schools with a student population of more than 3,300. Wesley College believes coeducation is the best way to prepare students for the world in which they will live. Coeducation is fundamental to the college's vision of learning, which includes learning to live with others. It's rich and comprehensive coeducational program promotes not only excellent academic results, but has a concentrated focus on the Arts, Sport, Outdoor Education and Community. The college has always been committed to being an innovative and leading educational institution, providing an education that encourages every individual student to flourish and be prepared for the challenges and opportunities of life after school.

Wesley College offers a unique commitment to the growth and development of each individual, a person who is open, inquiring, socially at ease, and who aspires to achieve excellence and personal best in all areas of endeavor. Coeducation at the college prepares girls and boys for the real world beyond school. While the curriculum certainly starts with numeracy and literacy, it expands much further to include a rich and varied choice of subjects. The Junior Schools are based on small homerooms, with specialist primary year's teachers who know their students well. The Middle School provides opportunities for young adolescents to learn and grow in ways that respect and acknowledge this critical phase of their lives. Senior School students are engaged in a diverse and varied set of learning experiences to ensure they develop to their fullest potential as knowledgeable, skilled and productive individuals.

Wesley College delivers an engaging and holistic education across three Melbourne campuses- Elsternwick Campus, Glen Waverley Campus, and St Kilda Road Campus. Each campus provides a unique environment where students benefit from Wesley's academic and teaching excellence, extensive co-curricular programs and strong focus on pastoral care.